中文_会议论文_将博数字资源平台

Multiple dose pharmacokinetics of artemisinin in rats by high performance liquid chromatography-tandem mass spectrometry

作者：Hong 更新时间：2019.05.21

Aim To investigate the pharmacokinetics of the antimalarial artemisinin in rats after single and multiple oral doses. Methods Six male Wistar rats were orally given a single dose of artemisinin 40 mg·kg-1(Group 1). Another six rats were orally given artemisinin at the same dose once daily for 5 consecutive days(Group 2). Artemisinin plasma concentrations，after single dose or after 5 consecutive doses，were determined by high performance liquid chromatography-tandem mass spectrometry(LC/MS/MS). Results The artemisinin pharmacokinetic parameters of Group 1 were compared with that of Group 2. The areas under the plasma concentration-time curve(AUC0-8)decreased from 126.53 h·ng·mL-1 of Group 1 to 39.91 h·ng·mL-1 of Group 2(p0.05). Conclusions The optimized LC/MS/MS method was successfully applied to the pharmacokinetic study of artemisinin in rats after single and multiple oral doses. The results suggested that artemisinin exhibits time-dependent pharmacokinetics.

Comparative Research on BPR Methods and Techniques

作者：Zhang Xuzhu，Zhang Yuandong 更新时间：2019.05.21

Various methods and techniques, such as UML methods, IDEF methods, workflow techniques and so on, have been developed through theoretical research and practical projects in the implementation of BPR. However, many managers or engineers who want to dramatically improve their organizational performance by implementing BPR often get confused by these miscellaneous methods and techniques. They often express difficulties in choosing the very method which is most suitable to their specific situation. In order to facilitate the BPR practitioners get a systematic view on how to reengineer their business process more efficiently, this paper integrates and rearranges the major BPR methods and techniques, analyzes their strengths and weaknesses. This paper also compares these methods and techniques vertically and horizontally in order to figure out the suitable conditions under which they can be employed, as well as the specific areas they are mainly dedicated. It can be served as an aid for practitioners to select proper methods and techniques in the implementation of BPR.

A Study on the Structural Dimensions of BtoB Brand Trust

作者：Wang Yi，Wang Xingyuan，Sun Ping 更新时间：2019.05.21

This paper chiefly made some research about the structural dimensions of brand trust in the market of BtoB. From the angles of the different factors which drive Brands' growth and the choosing of paths for brands' development, this paper suggests that BtoB brand trust should be divided into three dimensions: capacity trust, relationship trust and economical trust. Meanwhile, brands also take the three dimensions as the main methods to take development. Based on this, a measuring table of three-dimensioned brand trust was constructed in this paper, and it is tested by a sample of high-technology BtoB customer.

Study on Gas emission Rule and Prevention Technique for Low-Gas Coal Mine LTCC Working Face

作者：XIE Jun，CHENG Weimin，WANG Gang，YANG Peng 更新时间：2019.05.21

This paper lays emphasis on the prevention countermeasures of gas of the Longwall Top Coal Caving by the research of the occurrence rules of gas and the research of the rules of the gas emission in the low-gas mine. It brings forward the methods of preventing gas in the operation of the working face and affords the successful experiences in preventing gas effectively so that coal mine could be mined safely.

Analysis of Factors Impacting on SMEs to Implement Green Marketing Strategy

作者：LI Hong 更新时间：2019.05.21

Small and medium-sized enterprises (SME) must improve the market competition ability by implementing green marketing strategy in production, management and so on, while the whole world is increasingly paying close attention to the environmental protection. But there are many factors influencing on SME to put green marketing into action based on the concrete situations in our country. And it is difficult for SME to do it because there are many interactive relations among the influence factors at the same time. In order to solve it, this paper analyzes the factors influencing SME to put green marketing into action from market, government, business enterprise, customer etc., and research their relations, and unveil more clearly the relations between each pair of factors, quantitatively and qualitatively by DEMATEL approach to find out the key factors and the central issues. It is expected mat the conclusions are scientific decision-making gist for SME to implement green marketing strategy.

The Design of a High Cost Performance Piston outside Diameter Auto-measuring and Grouping System

作者：Yang Musheng，Zhang Yu，Bai Jinxing 更新时间：2019.05.21

The method and the performance of measuring the piston determine the quality and cost of the piston manufactured. Therefore, a simple, economic piston outside diameter automeasuring and grouping system is presented in this paper. Based on the industrial PC104 bus structure, it can not only measure and group the pistons, but also can manage the data. Meanwhile, through the modern statistical process analysis and control technology, the quality of the manufacturing process can be analysed and controlled. The well-fitted software and mechanotronics structure enables the system to be simple and reduces the whole cost.

用钻孔电视观测围岩分区破裂化

作者：李术才更新时间：2019.05.21

各位专家,下面是利用钻孔电视在淮南观测到的分区破裂化现象的结果向大家汇报一下,其中也有一些观点。该项目是由淮南矿业集团袁亮总工亲自组织实施的。淮南矿区井巷埋深相对比较深,近1000m,监测的巷道位置在-910m。巷道尺寸是宽5m,高4m,巷道断面如图1。

硅表面活性剂水溶液分散碳纳米管的研究

作者：庞瑾瑜，徐桂英更新时间：2019.05.21

自从日本科学家Iijima在1991年首次发现碳纳米管(CNTs)以来,CNTs因其不仅具备一般纳米材料所具有的表面效应、小尺寸效应、量子尺寸效应等基本效应,而且具有许多特殊的、十分优异的力学、电学、磁学、光学等性能而受到越来越多的关注[1-2],因而迅速成为纳米材料及其应用研究的热点。在实际应用中,CNTs分子之间的团聚往往会使它的优异性能无法表现出来,这大大妨

C_8F_(17)COOH/TTAOH/H_2O体系聚集行为的研究

作者：张娟，宋爱新，郝京诚更新时间：2019.05.21

近年来,无盐阴/阳离子表面活性剂混合体系由于其丰富的相行为引起了人们极大的兴趣,而氟表面活性剂由于其碳氟链的高表面活性、疏水疏油及化学稳定性等独特性质表现出了与碳氢表面活性剂差异极大的聚集行为,也引起了广泛关注。本文选择了全氟阴离子表面活性剂全氟壬酸和

铝螯合剂对染铝大鼠脑组织中铝及必需元素的影响

作者：巩泉泉，刘萍，禚金花，徐华雷，张雅楠更新时间：2019.05.21

目的:探讨铝螯合剂去铁酮(deferiprone,DFP)对染铝大鼠脑组织中铝、锌、铜、铁、钙、镁等元素的影响。方法:AlCl3染毒Wistar大鼠4周后分别给予不同剂量的DFP 2周,测定脑组织中铝、锌、铜、铁、钙、镁含量。结果:各给药组脑铝含量显著低于铝染毒组(P<0.01),高剂量组恢复至阴性对照组水平;各给药组大鼠脑组织中锌、铜、铁、钙、镁的含量与阴性对照组比较差异均无统计学意义。结论:在一定剂量范围内,DFP有较强的排铝作用,同时可以维持脑组织中锌、铜、铁、钙、镁代谢平衡。

镁剂抗心律失常作用研究进展

作者：李保应，李小利，高海青更新时间：2019.05.21

镁离子是人体成分中含量仅次于钠、钾、钙的第四位阳离子,三百多种酶反应的辅助因子,对细胞代谢和能量转换起到重要的调节作用。细胞内线粒体中镁离子浓度降低,线粒体发生肿胀,生成ATP的氧化磷酸化过程发生障碍,甚至使细胞变性和坏死。由于镁离子的负性肌力作用,可降低能量消耗,

铅对儿童生长发育及智力行为的影响

作者：陈浩更新时间：2019.05.21

铅作为一种有害于人体的微量元素,其危害,特别是对于儿童生长发育的影响,日益受到全社会的重视。现从铅对儿童生长发育、智力行为等的影响,阐述铅的危害及其生理、生化、病理及在体内代谢过程和发病机理,以提高广大医务工作者对儿童铅中毒危害的健康教育指导和正确认识,及时采取切实可行的早期健康干预和有效的防治措,达到保护儿童身心健康的目的。

泰山赤鳞鱼全同胞个体甲基化位点的差异研究

作者：王慧，高建刚，王树迎更新时间：2019.05.21

采用甲基化敏感扩增多态性(Methylation sensitive amplification polymorphism, MSAP)技术,检测了人工养殖的泰山赤鳞鱼全同胞子一代个体的甲基化位点差异。8对引物组合共扩增出127个位点,其中甲基化位点有97个,占总扩增位点的76.37%,表明:泰山赤鳞鱼仔鱼期基因组的甲基化水平较高。其中甲基化多态位点21个,占甲基化位点的21.65%,说明:全同胞个体的甲基化位点有较大差异,这可能与一些性状在后代中的分离和部分基因表达调控的改变有关。

CC1100无线通信模块在抄表中的应用

作者：王富斌，徐建政，韩洪更新时间：2019.05.21

以Silicon Labs公的C85051F310为微中央处理器、Chipcon(TI)公司的CC1100为射频收发器,设计一种能应用于射频无线抄表领域的低成本、低功耗、近距离无线通信系统。并对其硬件结构和编程的点进行了阐述。

基于在线递推闭环子空间辨识的电力系统模型预测阻尼控制

作者：叶华，刘玉田更新时间：2019.05.21

提出一种电力系统阻尼控制器设计的新方法。利用广域测量信息,闭环子空间算法辨识和在线递推更新包含主导低频振荡模式的系统降阶状态空间模型。基于辨识模型,设计了闭环形式的无限时域模型预测阻尼控制器。中国电科院8机36节点系统仿真结果表明,该控制器具有和传统PSS相互协调的能力,且可以有效地跟踪和适应系统拓扑和运行方式的变化,很好地抑制系统的区间低频振荡模式。

岩溶隧道施工风险评价方法与超前预报技术体系研究

作者：张庆松，李术才，李树忱，张之淦更新时间：2019.05.21

我国西部山区修建长大隧道工程中常会遇到岩溶和不良地质条件,施工中经常出现无法预料的地质灾害,如突水、突泥、坍塌等,造成极大的安全隐患。以湖北沪蓉西高速公路乌池坝隧道为工程背景,通过系统的补充地质调查和地质分析,探讨了隧道的岩溶发育规律,综合考虑岩组岩性、地质构造、地下水位和预计涌水量等因素,对隧道岩溶突水突泥的风险进行了分段评价,初步提出了岩溶隧道四级风险评价体系,在风险分级的基础上,对不同风险段超前地质预报方案进行了设计,研究对于高风险岩溶隧道的灾害防治具有一定的意义。

小檗碱对人食管鳞癌细胞的遗传毒性及生长抑制作用

作者：刘巧，刘招舰，姜海燕，王玉，徐冰，郭海洋，龚瑶琴，邵常顺更新时间：2019.05.21

目的探讨小檗碱(berberine,Ber)对人食管鳞癌细胞株EC9706的生长抑制作用及其作用机制。材料与方法:用Ber作用E9706细胞后,采用光学显微镜观察细胞形态学变化,用MTT法检测不同浓度Ber在不同时间对EC9706细胞增殖的影响;采用TUNEL法和流式细胞仪Annexin-V Alexa 488/PI法检测Ber对EC9706细胞凋亡的影响;PI染色法检测经Ber作用后EC9706细胞周期分布的改变;用Western blotting检测Ber对EC9706细胞p53,c-myc,cyclin D1蛋白表达的影响;用免疫荧光方法检测由DNA双链断裂引起的H2AX磷酸化。结果Ber体外能显著抑制EC9706细胞的生长增殖,其抑制作用与药物浓度及作用时间呈正相关关系,作用48h EC9706细胞IC_(50)值约为50μM;Ber作用后DNA双链断裂明显升高,G2/M期细胞比例显著上调,但凋亡现象不明显;同时实验还发现Ber可以明显上调p53的表达并抑制c-myc和cyclin D1蛋白表达。结论Ber可诱发DNA损伤,并可通过细胞G2/M期阻滞而明显抑制EC9706细胞的增殖,上调野生型p53蛋...

一X连锁腓骨肌萎缩症家系GX32基因突变分析

作者：林鹏飞，焉传祝，龚瑶琴更新时间：2019.05.21

腓骨肌萎缩症(Charcot-Marie-Tooth,CMT),又称为遗传性运动和感觉神经性疾病(HMSN),是一种临床和遗传异质性都很强的单基因遗传型周围神经病,发病率约为1/2500。患者主要表现为缓慢进展的对称性双下肢肌无力,鹤腿、垂足等,常伴有感觉障碍。根据电生理和组织病理学的改变,CMT可以分为Ⅰ型和Ⅱ型,其中CMTⅠ型为脱髓鞘型,神经电生理检查可见运动感觉神经传导速度严重下降,神经活检可见对称性节段性脱髓鞘,还可见到部分髓鞘再生,施旺细胞增生修复形成洋葱头样结构。CMTⅡ型为轴索变性型,运动感觉神经传导正常或轻度下降,神经活检主要以轴突变性为主。目前已经定位的CMT致病基因位点有40个位点,遗传方式有常染色体显性遗传、常染色体隐性遗传和X连锁遗传。其中最常见的是CMT1A(45%,PMP22基因突变,AD),CMT1B(5%,MPZ基因突变,AD),CMTX(12%,CX32基因突变,X-linked)。X连锁的CMT大部分为CX32基因突变,CX32基因编码蛋白为一种细胞间隙连接蛋白,组成细胞间的通道,促进了细胞间的离子和小分子物质的转运。目前已报道CX32基因的突变有250多种,大部分...

高分子蓄冷剂相变性能的实验研究

作者：赵红霞，韩吉田，周子鹏更新时间：2019.05.21

高分子蓄冷剂是一种新型蓄冷材料,但是目前对于其性能研究较少,生产厂家也很少给出产品性能参数。本文选取了两种市面上的高分子蓄冷剂,对其热性能-冷却凝固过程采用工程测量法进行了实验研究,测得相变温度曲线,探讨了不同因素对相变过程和过冷度的影响。通过实验发现高分子蓄冷剂在冷却凝固过程中存在一定的过冷度;过冷度受外界冷媒温度的影响较大,冷媒温度越低,过冷度越大。蓄冷剂的质量也影响到过冷度,质量越大过冷度越低。在凝固过程中蓄冷剂内存在一定温度梯度。降低过冷度并提高凝固过程中温度分布的均匀性是未来改进方向。

循环经济发展评价模式研究——以煤炭行业为例

作者：袁学良，王庆松，马春元，张凯更新时间：2019.05.21

循环经济发展评价模式研究,是循环经济理论研究的重要内容。采用熵技术修正的层次分析法对指标体系进行权重赋值,修正后的权重信息量较之修正前增大,可信度提高。煤炭行业循环经济系统作为一个复杂巨系统,涉及面广、影响因子多,采用模糊综合评价法对其进行综合评价,能够有效克服指标属性的模糊性,很好地反映出煤炭行业循环经济的发展现状和限制因素。本文构建的煤炭行业循环经济指标体系,给出的指标体系权重确定方法、评价等级分类以及多级模糊综合评价模型,可以对煤炭行业的循环经济发展水平进行有效测度,从定量的角度完善了循环经济理论与实践研究。

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