作者联系方式：Hong-Xia Yan(School of Pharmacy, Shanxi Medical University, Taiyuan, 030001, China;2Shanxi tumor hospital, Taiyuan, 030013, China)Jie Xing(School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, China)Li-Feng Zhang,Rui-Li Wang,Shu-Qiu Zhang(School of Pharmacy, Shanxi Medical University, Taiyuan, 030001, China)

关键词：时间依赖性，药代动力学，青蒿素，液相色谱-质谱分析法

会议名称：2008中国药学会学术年会暨第八届中国药师周

会议地点：石家庄

召开年：2008

摘要：Aim To investigate the pharmacokinetics of the antimalarial artemisinin in rats after single and multiple oral doses. Methods Six male Wistar rats were orally given a single dose of artemisinin 40 mg·kg-1(Group 1). Another six rats were orally given artemisinin at the same dose once daily for 5 consecutive days(Group 2). Artemisinin plasma concentrations，after single dose or after 5 consecutive doses，were determined by high performance liquid chromatography-tandem mass spectrometry(LC/MS/MS). Results The artemisinin pharmacokinetic parameters of Group 1 were compared with that of Group 2. The areas under the plasma concentration-time curve(AUC0-8)decreased from 126.53 h·ng·mL-1 of Group 1 to 39.91 h·ng·mL-1 of Group 2(p0.05). Conclusions The optimized LC/MS/MS method was successfully applied to the pharmacokinetic study of artemisinin in rats after single and multiple oral doses. The results suggested that artemisinin exhibits time-dependent pharmacokinetics.