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Multiple dose pharmacokinetics of artemisinin in rats by high performance liquid chromatography-tandem mass spectrometry
关键词：时间依赖性　　药代动力学　　青蒿素　　液相色谱-质谱分析法
Aim To investigate the pharmacokinetics of the antimalarial artemisinin in rats after single and multiple oral doses. Methods Six male Wistar rats were orally given a single dose of artemisinin 40 mg·kg-1(Group 1). Another six rats were orally given artemisinin at the same dose once daily for 5 consecutive days(Group 2). Artemisinin plasma concentrations，after single dose or after 5 consecutive doses，were determined by high performance liquid chromatography-tandem mass spectrometry(LC/MS/MS). Results The artemisinin pharmacokinetic parameters of Group 1 were compared with that of Group 2. The areas under the plasma concentration-time curve(AUC0-8)decreased from 126.53 h·ng·mL-1 of Group 1 to 39.91 h·ng·mL-1 of Group 2(p0.05). Conclusions The optimized LC/MS/MS method was successfully applied to the pharmacokinetic study of artemisinin in rats after single and multiple oral doses. The results suggested that artemisinin exhibits time-dependent pharmacokinetics.
简议抗菌药物临床合理应用的策略

抗菌药物的应用涉及临床各科室,正确合理应用抗菌药物是提高疗效,降低不良反应及减少或减缓细菌耐约性发生的关键。现将抗菌药物合理应用的策略简述如下。1。根据药动学/药效学(PK/PD)指导用药依据药动学/药效学,抗菌药物可分为两类:(1)时间依赖性药物,如临床常用的青霉素类、头孢菌素类、碳青霉烯类等药物。决定这些药物疗效的参数是血清(组织)中药物浓度高于最低抑菌浓度(MIC)的持续时间占给药间隔时间的百分比要超过40%-50%才能发挥治疗作用,还有MIC90的持续时间,即给药期间药物血药浓度超过致病菌的最小抑菌浓度(MIC)的时间越长,则抗菌活性越强。但当其血药浓度超过MIC的4倍以上时,即

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